Country: Uganda   -  Stage: 2


MDR-TB burden: 4.8 per 100 000
No. of trial sites: 1
Date first patient recruited: November 2017
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Uganda is one of the WHO-designated high TB burden countries. In 2017, estimated incidence for TB was 201 per 100 000 population and the mortality rate was 58 per 100 000 population. In 2017, 47,170 TB cases were notified. In the same year, the WHO estimated that 1.6% of new cases and 12% of previously treated cases were MDR/RR-TB cases. In 2015, MDR/RR-TB treatment was initiated in 250 patients, of which 74% were successfully treated.

STREAM Stage 2 is recruiting at one site in Kampala, Uganda, in partnership with the Makerere University Lung Institute and the Mulago National Referral Hospital. The Lung Institute was established in the Makerere College of Health Sciences to specialize in fighting lung diseases such as tuberculosis. In addition, Makerere University has significant experience implementing clinical trials as part of initiatives including Drugs for Neglected Diseases Initiative.

The Mulago Hospital was founded in 1913 and is the main national regional hospital for the entire country and a teaching hospital for the Makerere College of Health Science. With over 1700 hospital beds, they seek to provide super-specialized healthcare, to provide training and to conduct operational research in line with Ministry of Health requirements. The Hospital’s capacity for conducting clinical trials, its high volume of patients, and its expertise in managing tuberculosis are factors that contributed to selecting this partner in Uganda.

The STREAM site in Uganda is expected to recruit approximately 50 participants for STREAM Stage 2.

STREAM Uganda CAB hold outreach event at taxi rank, Kampala.